Explore the synthesis of camizestrant (AZD9833) through ChemAIRS® retrosynthetic analysis. This case study examines AstraZeneca’s reported discovery route and alternative synthetic strategies for the key chiral amine intermediate, including Ellman sulfinamide chemistry and ω-transaminase-mediated asymmetric amination. It also highlights process chemistry considerations such as large-scale raw material availability and biocatalytic reaction identification.